@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix quant: <http://eulersharp.sourceforge.net/2003/03swap/quantities#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix humdis: <http://www.agfa.com/w3c/2009/humanDisorder#>.
@prefix clinmorph: <http://www.agfa.com/w3c/2009/clinicalMorphology#>.
@prefix ther: <http://www.agfa.com/w3c/2009/therapy#>.
@prefix malneo: <http://www.agfa.com/w3c/2009/malignantNeoplasm#>.

<http://www.agfa.com/w3c/2009/malignantNeoplasm#>
	a owl:Ontology;
	dce:title """Malignant Neoplasia"""@en;
	dce:creator """Hans Cools, MD, Agfa Healthcare/Belgium"""@en;
	dce:contributor """Julia von Tresckow, MD, University Clinic of Cologne; Susanne Hagist, MD, University Clinic of Cologne""";
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal description of human malignant neoplasia."""@en;
	dce:format """OWL Full"""@en;
	dce:source """http://nciterms.nci.nih.gov/ncitbrowser/pages/multiple_search.jsf (NCI)"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

malneo:MalignantNeoplasia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """malignant neoplasia"""@en;
	skos:definition """Malignant cell proliferation."""@en;
	rdfs:subClassOf humdis:Neoplasia, [
		a owl:Restriction; owl:onProperty event:hasOutput; owl:someValuesFrom malneo:MalignantNeoplasm], [
		a owl:Restriction; owl:onProperty humdis:hasState; owl:someValuesFrom malneo:Malignant].

malneo:MalignantNeoplasm
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """malignant neoplasm"""@en;
	skos:definition """Abnormal tissue as a result of malignant neoplasia."""@en;
	rdfs:subClassOf clinmorph:Neoplasm, [
		a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom malneo:MalignantNeoplasia].

malneo:LymphoidHaematopoieticMalignantNeoplasia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """malignant neoplasia of lymphoid, haematopoietic and related tissue"""@en;
	skos:definition """Malignant neoplasia of lymphoid, haematopoetic and related tissue, so called leukemia and lymphoma."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasia.

malneo:LymphoidHaematopoieticMalignantNeoplasm
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """malignant neoplasm of lymphoid, haematopoietic and related tissue"""@en;
	skos:definition """Malignant neoplasm as a result of malignant neoplasia of lymphoid, haematopoetic and related tissue."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasm.

malneo:Melanoma
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """melanoma"""@en;
	skos:definition """Malignant neoplasia of melanocytes of skin."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasia.

malneo:TrunkMelanoma
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """melanoma of trunk"""@en;
	skos:definition """Malignant neoplasia of melanocytes of skin of trunk."""@en;
	rdfs:subClassOf malneo:Melanoma;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "269579005"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C43.5"^^clisko:icd10DT].

malneo:SecondarySkinMalignantNeoplasia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """secondary skin malignant neoplasia"""@en;
	skos:definition """Skin malignant neoplasia due to another human health disorder."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasia, [
		a owl:Restriction; owl:onProperty humdis:hasState; owl:someValuesFrom humdis:Secondary];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "94579000"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C79.2"^^clisko:icd10DT].

malneo:SecondaryBrainAndMeningesMalignantNeoplasia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """secondary brain and cerebral meninges malignant neoplasia"""@en;
	skos:definition """Brain and cerebral meninges malignant neoplasia due to another human health disorder."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasia, [
		a owl:Restriction; owl:onProperty humdis:hasState; owl:someValuesFrom humdis:Secondary];
	skos:exactMatch [
		#a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "94225005"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C79.3"^^clisko:icd10DT].

malneo:SecondaryColonAndRectumMalignantNeoplasia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """secondary colon and rectum malignant neoplasia"""@en;
	skos:definition """Colon and rectum malignant neoplasia due to another human health disorder."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasia, [
		a owl:Restriction; owl:onProperty humdis:hasState; owl:someValuesFrom humdis:Secondary];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "188444005"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C78.5"^^clisko:icd10DT].

malneo:MinimalResidualDisease
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """minimal residual disease"""@en;
	skos:definition """Small number of anaplastic cells remaining in a patient (during or) after treatment when the patient is in remission."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasia, [
		a owl:Restriction; owl:onProperty humdis:hasState; owl:someValuesFrom malneo:MinimalResidual].

malneo:Malignant
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """malignant"""@en;
	skos:definition """State of having anaplastic cells, with or without being invasive and/or metastatic and/or clonal."""@en;
	rdfs:subClassOf humdis:Malignant.

malneo:Anaplastic
	a rdfs:Class, malneo:Malignant;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """anaplastic"""@en;
	skos:definition """State of a human cell dividing rapidly and having little or no resemblance to a normal cell (NCI)."""@en.

malneo:MinimalResidual
	a rdfs:Class, malneo:Anaplastic;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/malignantNeoplasm#>;
	rdfs:label """minimal residual"""@en;
	skos:definition """State of a malignant neoplasia having a small number of anaplastic cells remaining after treatment when the patient is in remission."""@en;
	rdfs:subClassOf ther:Residual.